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Saturday, February 12 • 1:45pm - 2:45pm
Urinary Volatile Organic Compound Metabolites as Potential Biomarkers for Tinnitus

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Tinnitus, a phantom perception of ringing, buzzing, or other noise in the ears or head in the absence of an external sound source, is a common condition that affects about 10% of US adults (Bhatt et al. 2016). Oxidative stress is a major contributor to tinnitus. Exogenic risk factors for tinnitus, such as noise exposure and smoking, are known to cause oxidative stress. The direct evaluation of oxidative stress in the auditory system is not feasible in humans. However, the systemic oxidative stress, as assessed by urinary volatile organic compounds (VOC), might be used as a proxy measure for oxidative stress in the auditory system. We utilized the National Health and Nutrition Examination Survey (NHANES) database to investigate the relationship between urinary VOC metabolites and tinnitus. Our analysis identified four VOC metabolites (creatinine, N-acetyl-S-(2-cyanoethyl)-L-cysteine, N-acetyl-S-(3-Hydroxypropyl)-L-cysteine, and 2-methylhippuric acid) associated with tinnitus. Our results suggest that urinary VOC metabolites might be used as potential biomarkers for tinnitus.

Speakers
avatar for Ishan Sunilkumar Bhatt, Ph.D., CCC-A, F-AAA

Ishan Sunilkumar Bhatt, Ph.D., CCC-A, F-AAA

Associate Professor, University of Iowa
Dr. Ishan Bhatt is the Director of the Audiogenomics Research Laboratory in the Department of Communication Sciences and Disorders at the University of Iowa. He received his Ph.D. from the University of North Carolina at Greensboro and MASPL – Masters of Audiology, Speech and Language... Read More →
avatar for Sarah Kingsbury, BA, BS

Sarah Kingsbury, BA, BS

AuD Graduate Student, University of Iowa
Sarah Kingsbury is a Doctorate of Audiology (Au.D.) student at the University of Iowa and a Research Assistant in Dr. Ishan Bhatt's Audiogenomics Lab. Her clinical interests include cochlear implant programming and counseling, electrophysiological testing, and tinnitus management... Read More →
avatar for Nilesh Washnik, Ph.D

Nilesh Washnik, Ph.D

Assistant Professor, Ohio University
Nilesh Washnik currently works as an Assistant Professor at the Department of Communication Sciences and Disorders, Ohio University, Athens. Nilesh received his PhD in Audiology from the University of North Carolina, Greensboro. His areas of research are Noise-Induced Hearing Loss... Read More →


Saturday February 12, 2022 1:45pm - 2:45pm CST
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Attendees (2)